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In individuals with elevated BP, SGLT2i lower systolic BP by 39 mmHg [5, 11]

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Severe nausea on GLP-1 medications combined with illness-related vomiting creates a dangerous situation where: Dehydration can develop rapidly You cannot absorb oral medications or nutrients The GLP-1 medication may worsen gastrointestinal symptoms Risk of electrolyte imbalances increases When to seek emergency care : If you cannot keep any fluids down for 12+ hours, notice dark urine, feel dizzy upon standing, or have a rapid heartbeat, seek medical attention immediately

Instead, the central GLP-1 system operates independently, driven by physiological signals such as gastric distension and neural inputs, rather than circulating GLP-1

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