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A phase 2B trial (NCT02279524) showed that although aramchol 600 mg had no impact on liver fat fraction, it provided favorable outcomes in liver fibrosis and ALT levels, suggesting it may be a promising therapy for MASH with fibrosis
Polymeric nanoparticles and micellar architectures enhance aqueous dispersibility and mucosal absorption by reducing particle size to the nanometre range, thereby increasing surface area and contact time with intestinal epithelium, whilst lipid-based delivery systems exploit bile-mediated solubilization to improve intestinal bioavailability (Figure 1)
doi: 10.1001/jamainternmed.2020.0994
J Org Chem 78(2):320327 Pratley RE, et al (2018) Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial Lancet Diabetes Endocrinol Ralhan K, KrishnaKumar VG, Gupta (2015) Piperazine and dbu: a safer alternative for rapid and efficient fmoc deprotection in solid phase peptide synthesis
External factors, such as diet culture, can set unrealistic expectations and standards
Diabetes Care 2018;41(8):16631671
