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It was originally approved by the FDA for type 2 diabetes and is now also approved for weight management in eligible patients

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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Pontzer H, Yamada Y, Sagayama H, Ainslie PN, Andersen LF, Anderson LJ, et al

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Specifically, in the absence of an orthosteric ligand, compound 2 displayed a strong partial agonism in cAMP response (80% E max of GLP-1), a weak partial agonism in pERK1/2, and no detectable calcium mobilization response 29,30

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