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The GLP-1 RA and Its Relationship with Brain Insulin Resistance Brain IR can be defined as the failure of brain cells to respond to insulin, and the lack of response may be due to the downregulation of insulin receptors, an inability of insulin receptors to bind insulin, or faulty activation of the insulin signaling cascade.16 Insulin receptors are distributed throughout the brain, but have the highest concentration in the olfactory bulb, cerebral cortex, hypothalamus, hippocampus, and cerebellum.17 Insulin binds to the insulin receptor, phosphorylates the insulin receptor substrate (IRS), activates the phosphoinositide-3 kinase (PI3K) and mitogen-activated kinase (MAPK) pathways, and modifies the activity of several downstream effectors

However, in patients with pre-existing normal to low blood pressure, special consideration must be taken to ensure their pressure doesnt drop to dangerously low levels

We just dont know enough yet to say for sure

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WeightWatchers has confirmed it no longer offers compounded semaglutide, instead providing patients with Novo Nordisk's branded drug Wegovy

doi:10.1016/s2213-8587(15)00482-9