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In a population pharmacokinetic analysis of plasma dofetilide concentrations, the mean dofetilide clearance of dofetilide was 16% lower in patients on thiazide diuretics

Additionally, the medication's gastrointestinal side effects may lead to dehydration, which can concentrate urine and affect its odor

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Some studies have examined formal cognitive testing, with mixed results

The same is true of Metformin: the available scientific data similarly reinforces its prescription as a weight loss aid, and we have a myriad of positive patient testimonials to show for it

A related study explores the use of 1,4-dinitroimidazoles for macrocycle formation