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In the SURMOUNT-5 trial, participants without diabetes taking the 15mg dose lost an average of 20.2% of their body weight over 72 weeks

What makes these medications conceptually coherent, beyond the individual findings, is that they fit naturally with a view of addiction as a disorder of dysregulated reward, stress, and self-regulation

Baseline Weight: Baseline weight also plays a crucial role

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The gradual dose titration schedule is specifically designed to minimise these gastrointestinal symptoms

At 2.5 mg/mL, it equals 20 units on a U-100 syringe
