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#Pharma has been aiming for years to achieve magnitude of #weightloss similar to #bariatricsurgery, and now multiagonists prove that can be achieved. * HOWEVER, not everyone needs bariatric surgical magnitude of wt loss (and the discontinuations due to perceived excessive wt loss in this reta trial prove this point)

Body mass index and breast cancer risk according to postmenopausal estrogenprogestin use and hormone receptor status

The two main drugs differ: semaglutide (Ozempic, Wegovy) targets GLP-1 receptors only, while tirzepatide (Mounjaro, Zepbound) hits both GIP and GLP-1 receptors which is why clinical trials show tirzepatide producing more weight loss at comparable doses

The new FDA regulatory requirement to ensure that new diabetes medications are not associated with increased CV risk has produced intriguing findings

Despite their popularity, GLP-1 receptor agonist use to date has been limited to patients willing and able to administer the medication by SC injection

Third-party testing certificates and proper storage throughout the supply chain are indicators of quality sourcing