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In vitro, in differentiated human DA neurons, IR was associated with increased -synuclein and ROS levels, as well as mitochondrial depolarization, which may be mediated by polo-like kinase-2.177 In vivo, mitochondrial dynamics-related factor Parkin was significantly reduced in the substantia nigra of a mice fed a high-fat diet and a diabetic mice, leading to the accumulation of Parkin-interacting substrate and the reduction of PGC-1.41 Also, high glucose levels may modulate Parkin/PINK1-mediated mitochondrial autophagy in DA cells through the thioredoxin-interacting protein.178 All the above mechanisms suggest that diabetes-related metabolic factors may promote PD by regulating the mitochondria

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Skarbaliene J, Secher T, Jelsing J et al (2015) The anti-diabetic effects of GLP-1-gastrin dual agonist ZP3022 in ZDF rats

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Side Effects and Safety Common effects: nausea, vomiting, diarrhea, constipation, abdominal pain, decreased appetite, dyspepsia, fatigue, and injection-site reactions