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The most common denial reasons in 2026 are insufficient BMI documentation, missing comorbidity ICD-10 codes, lack of lifestyle intervention notes, and step therapy not completed

55 Comparison to traditional antihypertensive therapies and clinical relevance Traditional antihypertensive medications, such as angiotensin-converting enzyme (ACE) inhibitors, thiazide diuretics, or calcium channel blockers, typically reduce SBP by 7 to 11 mm Hg (Table 4)

Either pathway should include baseline labs, documented eligibility criteria, side-effect tracking, and scheduled reassessment intervals

Taken together, these data support the use of an individualized, multi-mechanistic treatment approach

It releases inflammatory signals into the bloodstream