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The biological evaluation of the newly synthesized chemical agents demonstrated that molecule 63 possesses the most potent enzyme inhibition activity, with an IC 50 of 17.7 M (Figure 7)
Drucker DJ, et al
Semaglutide mimics the action of the naturally occurring hormone GLP-1, which is involved in the regulation of blood sugar levels and appetite
The two most important incretin hormones responsible for this effect are glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP)-1
doi: 10.1210/edrv-9-3-295
