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This guide covers clinical evidence, safety considerations, biomarker insights, and how to have an informed conversation with your healthcare provider about dual therapy

However, glucose exposure may damage the structure and function of the peritoneal membrane and cause systemic metabolic complications, including insulin resistance and cardiovascular disease, underscoring the need for glucose-sparing strategies with alternative solutions, such as solutions with icodextrin and amino acids as osmotic agents, and glucose-based, less bioincompatible fluids with physiological pH and reduced glucose degradation products

Retatrutide, a first-in-class triagonist medication, is showing unprecedented results in clinical trials

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In the SURPASS-4 study, which enrolled patients with established cardiovascular disease, weight-loss independent effects explained 33% to 57% of difference in SBP change between tirzepatide and insulin glargine groups

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