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Description
Injectable GLP-1 RAs are not meal-dependent, while oral semaglutide must be taken on an empty stomach with a small amount of water

Sioux Falls therapist Faith Carlson said the GLP-1s are good, but offered some caution

Through several mechanisms, including direct interaction with SUR1 and membrane depolarization, intracellular calcium mobilization, and insulin granule priming modification, EPAC2 activation may promote the exocytosis of insulin granules [55, 56]

Much better

Individuals with a history of thyroid cancer or pancreatitis should avoid these medications

JAMA 2023
