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Theyre mathematically linked by: G = RT ln(Kd) Example Suppose you have two drug candidates, A and B, targeting the same protein: - Drug A: Kd = 10^-9 M (1 nM), G = -12.8 kcal/mol - Drug B: Kd = 10^-6 M (1 M), G = -8.6 kcal/mol - Drug A has a lower Kd and more negative G, indicating higher binding affinity and stronger, more stable binding

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