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However, a significant induction of Glp1r and Ppar mRNA transcripts was detected in metformin-treated INS-1 832/3 cells at both glucose concentrations (Fig

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Taken together, these findings suggest that the effects of GLP-1RAs in breast cancer are context-dependent and may vary according to tumor subtype and exposure conditions, warranting caution when extrapolating high-dose preclinical observations to clinical safety

In August 2024, a study published in JAMA Network Open found that semaglutide-associated suicidal ideations showed significant disproportionality compared with all other medications and their suspected adverse drug reactions (ADRs

6X18: Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, enel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D

To ascertain whether metformin exerted a direct effect on islet beta cells, we incubated INS-1 832/3 cells with or without metformin at 5 or 20 mmol/l glucose