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The case of Eli Lillys tirzepatide suggests we may be approaching a ceiling in terms of efficacy: aiming for weight loss beyond 20% might be neither necessary nor clinically sound

In addition, a GLP-1R agonist was shown to act indirectly through gamma-Aminobutyric acid neurons to inhibit NPY/AgRP neurons in the ARC44)

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Living with Type 2 diabetes often requires more than lifestyle adjustments and metformin

SmartDose: Personalizing Titration for Adherence and Sustainable Results Traditional GLP-1 prescribing follows a one-size-fits-all titration schedule dictated by the drug label

The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript