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Researchers collected data from adults aged 40 years and older with type 2 diabetes from Canada, Denmark, Norway, South Korea, Sweden and Taiwan who filled a prescription for a GLP-1 receptor agonist (n =

GLP-1 receptor agonists have changed the way obesity and metabolic disease are treated

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Multiple randomized controlled trials and meta-analyses in patients with type 2 diabetes and obesity demonstrate that GLP-1RA therapy either preserves or modestly increases bone mineral density (BMD) at key skeletal sites lumbar spine and hip, GLP-1RAs also favorably modulate bone turnover markers, increasing bone formation markers (P1NP, osteocalcin, bone-specific alkaline phosphatase) and reducing bone resorption markers (-CTX), suggesting a net positive or neutral effect on bone remodeling