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Acknowledgments We thank Henrique Malaco for his helpful discussions

the interaction was not significant

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This sustained action leads to a far stronger effect on appetite suppression and blood sugar control than what the body can achieve naturally, which is why these medications are highly effective treatments for type 2 diabetes and obesity

When given orally, fructose is a far less potent GLP-1 secretagogue relative to an isocaloric load of glucose [249]