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The plateau is not a failure of the medication

[DOI] [PMC free article] [PubMed] [Google Scholar] 163.Prado C.M., Phillips S.M., Gonzalez M.C., Heymsfield S.B

Future studies should determine whether retatrutides metabolic effects arise from direct tissue actions or secondary weight-loss mechanisms

While GLP-1R signaling represents a mechanistically distinct and clinically relevant target in the treatment of addiction, continued exploration of its neurocircuit-level actions, safety profile, and patient-specific responses may open new frontiers in the integration of metabolic and psychiatric care

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These should remain refrigerated until needed