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While GLP-1R-decorated nanocarriers can effectively bind and internalize into target cells, quantitative imaging studies indicate that less than 2% of the internalized nucleic acid payload escapes from endosomal compartments into the cytosol

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But according to a barebones public notice and Stats sources, a single person has been granted early access through the expanded access, aka compassionate use pathway, which is typically used to grant access to patients with a serious or immediately life-threatening disease or condition and who are not able to enroll in a clinical trial, often because they are too ill