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Originally developed for type 2 diabetes, semaglutide is now frequently used for weight management because of its ability to regulate appetite and blood sugar

Literature data indicate that PWS patients have lower birth weight and a higher prevalence of preterm delivery and SGA ( Thyroid disorders are quite common in these individuals, and the dysregulation of the hypothalamic-pituitary-thyroid axis is the most frequent cause ( Supplementary Table 1 )

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Advertisement With this dual agonism, tirzepatide has demonstrated the largest weight loss in a randomized trial of any medication for obesity/overweight to date, with its highest dose achieving a 22.5% reduction relative to placebo at 72 weeks in the phase 3 SURMOUNT-1 trial ( N Engl J Med

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