can semaglutide make depression worse Some patients have reported a kind of emotional flattening while on GLP-1 drugs. Online, the phenomenon has taken on a name — anhedonia — and, more colloquially, “Ozempic personality.” GLP-1 Agonists Can Affect Mood:
Description
Maybe you get tired, burpy, bloated, refluxy, or afraid to eat the wrong thing

In the NHS, Wegovy is typically prescribed through specialist weight management services for patients meeting specific NICE criteria (TA875), with treatment duration limits

Why glucocorticoid withdrawal may sometimes be as dangerous as the treatment itself
Side effects Nausea, vomiting, bloating, acidity, constipation, or reduced tolerance can make some people want to stop

GLP-1R-mediated modulation of reward circuits extends to the amygdala and medial prefrontal regions

Novo Nordisk and Eli Lilly have been slower to pursue addiction indications for the medicines, while running trials proving their cardiovascular benefits, effects on kidney disease, heart failure and sleep apnea
