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The expression of TNF- , MCP-1, and F4/80 mRNA levels is increased in the testis and significantly decreased the sperm motility and activity in diet-induced obesity mice, and exenatide (24 nmol/kg/day) treatment suppressed the expression of TNF- , MCP-1, and F4/80 mRNA levels in testis and improved sperm quality in diet-induced obesity mice [111]