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Randomized controlled trials indicates that combination therapy achieves greater reductions in HbA1c compared with either agent alone

Compared to placebo, patients receiving liraglutide had significantly greater weight loss after 6-month therapy [MD6.0 kg (95% CI,8.66 to3.33)

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A deeper understanding of the gutmicrobiomebrain axis may ultimately enable personalized, microbiota-guided therapies that treat both the physiological and psychological dimensions of obesity and depression, marking a major step toward holistic and precision medicine.