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GLP-1s are not cheap

They can cause a range of reactions, from mild skin rashes to more serious problems like difficulty breathing

In fact, people with diabetes are twice as likely to have heart disease or stroke.[2] The leading cause of morbidity and mortality for individuals with diabetes is atherosclerortic cardiovascular disease (CVD), which includes coronary heart disease, cerebrovascular disease or peripheral arterial disease

Glucagon-like peptide-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR), is broadly expressed on the surfaces of various cells, including the pancreas, intestine and brain [8]