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Other recognised side effects include: Injection site reactions (redness, itching, bruising) Decreased appetite Gallbladder disease (cholelithiasis, cholecystitis) Rare but serious adverse effects that require immediate medical attention include: Pancreatitis (severe, persistent abdominal pain) semaglutide should be discontinued if pancreatitis is suspected Diabetic retinopathy complications (in patients with pre-existing retinopathy) Acute kidney injury (particularly in the context of severe dehydration) Severe allergic reactions (anaphylaxis, angioedema) Patients should be counselled about these potential effects before starting treatment and provided with clear guidance on recognising symptoms that warrant urgent medical review

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But the experience, quality, and results differ substantially

The glucose consumption of the brain and its dependence on the liver