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Trulicity (dulaglutide) is another example

Lilly's Yuffa said uptake will depend on factors including patient and physician awareness and how smoothly the healthcare system handles demand, which will take time to build

Cell 132 , 10251038 (2008)
The Indiana bill passed, but the Kentucky bill failed to advance

Why Retatrutide May Show More Reward Blunting in Some Research Subjects The most plausible explanation lies in signal stacking : GLP-1 reduces hedonic and reward-driven feeding GIP modulates metabolic and central signaling Glucagon increases energy expenditure and output-oriented physiology Together, these signals may: Further suppress reward-seeking behaviors Reduce the relative salience of pleasure-based stimuli Shift behavioral and metabolic priorities toward efficiency and fuel utilization In some nervous systems, this tradeoff may be observed as reduced reward responsiveness or anhedonia-like features
That might sound like a small number on paper
