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These findings suggest that even in a weight-reduced state from untreated obesity, the DVC amylin and GLP-1 receptors continue to be a viable drug target for sustained weight loss

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454456 MMPs are a class of enzymes that play a crucial role in the breakdown of extracellular matrix components

New England of Journal Medicine , 2021;384(11):989-1002

1.5 Other possible pleiotropic effects of Tirzepatide Pleiotropic effects of GIP receptor stimulation in other tissues, mediated by mechanisms other than typical protein G-coupled receptor pathways, might bring additional benefits