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Post-prandial levels of portal blood glucose are elevated and insulin levels decreased in rats with knockdown of GLP-1R in vagal afferent neurons, suggesting that GLP-1 also regulates blood glucose via activation of vagal afferent GLP-1 receptors [518]
Therefore, an anti-mouse GIPR surrogate antibody was used to conjugate with the GLP-1 analogue peptide to generate an AMG 133 murine surrogate to assess its effect in pharmacology studies in mice
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