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Amor S, Puentes F, Baker D, van der Valk P

Next-Generation Oral Small-Molecule GLP-1s Unlocking Primary-Care and Emerging-Market Volume Orforglipron, GSBR-1290, and VK2735 demonstrated double-digit weight-loss efficacy in Phase 2 studies without injection-related barriers, attracting strong interest from primary-care physicians

Unless stabilized and formulated to overcome these obstacles, orally delivered peptides suffer from poor bioavailability and short half-lives, which may limit efficacy even with frequent dosing

doi: 10.1016/S2213-8587(25)00006-3.]

The stimulation of these receptors may cause delayed emptying, leading to gastroparesis

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