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The future will likely require smarter biomarkers, better patient selection and combination therapies aimed at multiple pathways simultaneously

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Trister also talked about plans for the Study Watch and offered views on the Alzheimers research landscape and AI development and regulation in a new era of uncertainty.

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Nevertheless, bone consequences of intentional weight loss interventions in PwO are well known: (i) significant weight loss induced by caloric restriction and bariatric surgery results in accelerated bone turnover and bone loss, and (ii) unlike caloric restriction interventions, PwO experience a substantial deterioration in bone microarchitecture and strength associated with an increased risk of fracture after bariatric surgery especially malabsorptive procedures