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So, in effect, the GLP-1s replace a hormone that gets low when people try to lose weight, thus allowing for sustained weight loss without the person feeling hungry all the time

While you do not need the full clinical version, adapting its approach is useful

In reality, weight gain and loss are far more nuanced

Make it the anchor of every eating occasion not an afterthought you fill in at the end

13 While GLP-1 agonist-induced weight loss can decrease mechanical load through the musculoskeletal system and improve aspects of physical function, the resulting negative effects on tendons, impaired muscle function, and joint degradation can persist after a healthy weight has been achieved

In addition to its incretin action, GLP-1 acts on the GLP-1 receptor (GLP-1R) in the brain to suppress feeding