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For detailed control analyses of the Baseline and Vehicle conditions, see Control analyses of Vehicle and Baseline data section of the Supplementary Results

Holding duration will vary based on frequency of administration, with day of surgery for daily formulations and a week prior for weekly formulations being the current recommendation
Most DPP4is exhibit low and reversible plasma protein binding (ranging from 9.3% to 38%), except linagliptin (70%) and alogliptin (~100%)

And so, the system is already there to make these peptides functional. This delivery platform also allows the natural versions of these peptides to be used, potentially lowering the risk of side effects, he notes

Clinical trials have demonstrated weight loss ranging from approximately 10% with GLP-1 agents at weight management doses (e.g., semaglutide 2.4 mg in the STEP trials) to over 20% with tirzepatide at higher doses (SURMOUNT trials)

Scientists are currently investigating their potential to slow Alzheimers and Parkinsons disease progression
