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doi: 10.1016/j.molmet.2022.101550 51 RazzakiTSWeinerAShuklaAP

Diabetes mellitus (DM) is a group of metabolic diseases classified by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both

Moreover, its expression appears to be influenced by metabolic stress, with it being increased in islets from diet-induced obese mice compared to normal weight animals (104), but lower in human islets from diabetic compared to non-diabetic donors (98, 99, 104)

03Dose Changes, Step-Ups, and Missed-Dose Notes Doses change over time

It is an investigational triple hormone receptor agonist

95% CI: 0.21 to 0.16