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The FDAs Adverse Event Reporting System (FAERS) database includes 442 cases of adverse events associated with compounded semaglutide, including seven deaths

Madero M, Katz R, Murphy R, Newman A, Patel K, Ix J, et al

Tirzepatide and Blood Pressure Reduction: Stratified Analyses of the SURMOUNT-1 Randomised Controlled Trial

Thus, this study documented a reduced efficacy of GLP-1 RAs and tirzepatide in terms of glucose-lowering and weight loss effects among patients with T1D and obesity likely related to genetic causes

In both cases, starting with a low dose and gradually increasing it helps minimize these side effects
