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11 Considering GIP analogues, Gly 2 GIP shows improved cAMP activity and insulinotropic activity in vitro, 20 while the cAMP activity of D-Ala 2 GIP matches that of GIP

This tripartite mechanism may help explain why the compound has shown effects on hepatic fat content alongside weight loss in early clinical data

The two drug classes (SGLT2 inhibitors and GLP-1RAs) differ largely in their pharmacological actions

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