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The review urges nurse practitioners to balance expanding clinical promise with careful prescribing, patient education, monitoring, access advocacy, and vigilance for gastrointestinal, endocrine, pregnancy-related, and rare serious risks.

Prior auth criteria, BMI thresholds, copay estimates, Medicare Advantage update, and how to appeal.

A randomized study found that holding one preprocedure dose of GLP-1 therapy reduced clinically significant residual gastric volume during EGD.

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A 2026 case report describes a 34-year-old man with obesity and alcohol use disorder whose semaglutide treatment for weight loss was associated with a marked drop in drinking over 10 months, with his AUDIT score falling from 27 to 7 and alcohol use dropping from about 15 drinks per week to half a beer per month