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Absolute event rates remain low, and no consistent causal relationship has been confirmed

In addition, mechanical activation of chondrocytes, which occurs during injury, activates extracellular matrix degradative enzymes including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) [6]

doi: 10.1172/jci.insight.153732 [DOI] [PMC free article] [PubMed] [Google Scholar] 270

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Raufman originally found the Gila monster after John Pisano, a biochemist who specialised in looking for novel substances in venoms, sent him on a venom-mining expedition