glp 1 glucagon like peptide 1 Multiple physiologic effects of glucagon-like peptide-1 (GLP-1) Glucagon-like peptide-1 receptor: mechanisms and

Exenatide readily enters the brain when injected intravenously into mice (102)

Genetic factors may also influence the glycaemic response to GLP-1 RAs, although their impact is uncertain, while a genome-wide study did not find a link between genetic variants and weight loss response to this drug class [3], suggesting that different mechanisms are involved in the glycaemic and weight loss effects of GLP-1 RAs

It is crucial to emphasize that these mechanisms represent hypotheses rather than established pathophysiology

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GLP-1 and GLP-1(936) are also cleaved by neutral endopeptidase (NEP24.11), yielding GLP-1(2836), a 9amino acid carboxy-terminal peptide with biological activity (11)