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Description
They lower glucose levels by stimulating insulin release from pancreatic beta-cells in a glucose-dependent fashion and by inhibiting glucagon release from the pancreatic alpha-cells

Diabetes 2012;61:275362
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Mild to moderate side effects are often observed in the early weeks (~first 6) of medication use and during dose escalation

Furthermore, DPP-IV gene silencing inhibited PTC cell proliferation and enhanced apoptosis
There is a direct correlation with dosing and the degree of proteinuria reduction