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Semaglutide works by mimicking a natural hormone (GLP-1) that targets areas of the brain responsible for appetite regulation

We next assayed cAMP-dependent protein kinase (PKA) (27, 35), ERK (36), and eNOS (37) activations as putative downstream targets of GLP-1(2836)induced cAMP and/or molecules known to be involved in GLP-1mediated cytoprotection (21)

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Each treatment group was divided into two cages with three mice in each cage

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