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Stricter FDA rules are reshaping GLP-1 access, opinions on regulation, and growing interest in alternatives like liraglutide.
GLP-1 medications may offer benefits beyond weight loss and diabetes management, including better outcomes for breast cancer patients who are obese or have type 2 diabetes, according to new research.
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An expected surge in generic GLP-1s is anticipated to reshape not only pharmaceutical pricing and access but also the global MedTech ecosystem supporting drug delivery.
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Both ligands had similar cAMP potency but the exendin-4-C16 showed 2.5-fold bias towards G protein recruitment and a 60% reduction in -arrestin-2 recruitment efficacy compared to exendin-4, as well as reduced GLP-1R endocytosis and preferential targeting towards recycling pathways
