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Thus, incubating human and rodent islets under high glucose conditions results in increased expression of PC1/3 and increased secretion of GLP-1 (101, 108110), while exposure of -cells to the proinflammatory cytokine, interleukin-6, also increased GLP-1 secretion (112)

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There are several potential reasons for the reduced magnitude of effects on primary endpoints related to cognitive decline

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Larger, longer-duration trials with robust outcome measures are needed to determine whether these medications can meaningfully alter the course of Parkinson's disease or improve quality of life for patients