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This mechanism produces weight loss without systemic hormonal changes, making it mechanistically independent of appetite or metabolic rate

doi: 10.1677/joe.0.1530423 64 CaravaggioFBorlidoCHahnMFengZFervahaGGerretsenPet al

Body weight, glycated hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), fasting insulin (FINS), and fasting C-peptide (FC) were measured in patients both before (pre-tirzepatide group) and after (post-tirzepatide group) treatment

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