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Orforglipron , an oral GLP-1 agonist, has shown the ability to maintain weight loss in patients switching from injectable therapies

The most common side effects are nausea, stomach pain and diarrhea

PlexusDx Precision Peptide Genetic Test ($99 add-on after your first month of treatment) analyzes your GLP1R rs6923761 variant and 13 other peptide-pathway markers to predict your likely response pattern

Blood glucose should be monitored closely and a medication review sought from your GP or diabetes specialist (see NICE NG28: Type 2 diabetes in adults: management)

For example, a retrospective analysis in older adults, vaccinated and unvaccinated, with risk factors for severe disease showed a 25% lower risk of developing Long COVID after treatment with Paxlovid

If you lack an approved sharps container, use a sturdy household container made of heavy-duty plastic with a puncture-resistant lid