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As GLP-1 and GLP-2 have become important targets in the treatment of type 2 diabetes, obesity and malabsorptive conditions 16,17,62 , we therefore characterized gut microbiome signatures in DIO mice treated with liraglutide, a selective GLP-1 receptor agonist, or GUB09-145, a potent dual GLP-1/GLP-2 agonist 26

In November 2025, the Trump Administration announced an upcoming demonstration project that will extend coverage for GLP-1s to people living with obesity and related complications starting later in 2026

GLP-1RA use was associated with a modestly increased risk of erectile dysfunction, with a hazard ratio of 1.26