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We also describe the development of incretin-based pharmacotherapy, starting with exendin- 4 and ending with the identification of multi-incretin hormone receptor agonists, which appear to be the next major step in the fight against T2DM and obesity
Molecular communications in the gutbrain axis, between the central nervous system and the gastrointestinal tract, are critical for maintaining healthy brain function, particularly in aging

Moreover, the combined GLP-1 mechanisms of weight loss and delayed carbohydrate absorption may also be the key drivers of remission of type 2 diabetes and reduced cardiovascular events found by GLP-1 analogues.

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Combining exercise with GLP-1 RA liraglutide results in significant weight loss while preserving bone health in adults with obesity.
