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This article explains what the clinical trials actually show, why the body responds the way it does when GLP-1 medications are discontinued, and what a realistic maintenance plan looks like for most people

Sato T, Tadokoro T, Sonoda T, et al

Technically, yes, it does activate GLP-1 receptors

GLP-1R was detected in mouse and human macrophages, neutrophils, eosinophils, and lymphocytes

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