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In a complementary preclinical component of the same study, administration of the GLP-1R agonist AC3174 reduced ethanol intake in alcohol-dependent but not nondependent C57BL/6J mice exposed to a chronic intermittent ethanol vapor paradigm

A single 800 g/kg dose of liraglutide administered 2 hours before LPS exposure attenuated lung injury and reduced lung Tnf , Il6 , and Il1b expression in control but not in Glp1r / mice (76)

J Neuroinflammation 5(1):19 Wang Y, Wang W, Li D, Li M, Wang P, Wen J, Liang M, Su B, Yin Y (2014 Nov) IGF-1 alleviates NMDA-induced excitotoxicity in cultured hippocampal neurons against autophagy via the NR2B/PI3K-AKT-mTOR pathway

Immunohistochemical analysis has revealed GLP-1 R expression in the acinar and ductal epithelium of the lacrimal gland, although this expression is significantly downregulated in diabetic models

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Beyond glycemic control, these agents provide distinct and complementary cardiorenal benefits through mechanisms such as hemodynamic modulation, anti-inflammatory effects, and metabolic adaptations