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Cardiovascular exercise provides additional metabolic and cardiovascular benefits, but should complement rather than replace resistance training

In these trials, dosing was deliberately conservative at the outset in order to balance efficacy with tolerability

The second patient was a 46 year-old female

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Exendin-4 stimulation triggered a small increase in mitochondrial membrane potential under 6 mM glucose conditions, with this response further enhanced under increased (20 mM) glucose concentrations