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2 In parallel, hypertension is highly prevalent among individuals with T2DM, affecting approximately 78% of patients

Time window and exit rules: a sufficient treatment window (36 months) should be reserved to achieve clinically meaningful weight loss (typically threshold of 5%10%) alongside IR improvement
Additionally, semaglutide slows gastric emptying, meaning food stays in the stomach longerprolonging the feeling of fullness after meals. These combined effects explain why semaglutide for weight loss has become a widely discussed and clinically validated approach in obesity management

18 Similarly, the claim-based frailty index was estimated from the administrative dataset using a previously validated methodology that incorporates Current Procedural Terminology (CPT) codes, Healthcare Common Procedure Coding System (HCPCS) codes, and ICD codes
These are established physiological facts, not speculation
